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Breast Cancer Tumor Grading
Histologic Tumor Grading
For breast cancer recurrence and survival 2,3,
histologic tumor grade is a well established
prognostic factor. Histologic grade also has
predictive value with respect to patient benefit from
chemotherapy.3 However, traditional histologic
grading is a subjective assessment, with potential
for both intra- and inter-observer variability. With
this approach, approximately half of all breast
cancers are classified as intermediate grade.
Molecular Tumor Grading
A new technology that refines tumor grading,
molecular tumor grading provides an objective and
robust assessment of tumor grade and proliferation,
removing much of the ambiguity inherent in
histologic grading. In addition, restratification of
intermediate grade tumors through quantification
of low grade or high grade molecular features is
informative for treatment decisions. |
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References:
1 Ma X-J, Salunga R, Dahiya S, et al: A five-gene molecular grade index and
HOXB13:IL17BR are complementary prognostic factors in early stage breast
cancer. Clin Cancer Res. 14(9); 2601-2608, May, 2008.
2 Cianfrocca M, Goldstein LJ: Prognostic and predictive factors in early-stage
breast cancer. Oncologist, 9:606-616, 2004
3 Schnitt SJ. Traditional and newer pathologic features. J Natl Cancer Inst Monogr.,
22-26, 2001
4 Whitfield ML, Sherlock G, Saldanha AJ, et al. Identification of genes periodically
expressed in the human cell cycle and their expression in tumors. Mol Biol Cell.,
13:1977-2000. 2002. Also http://genome-www.stanford.edu/Human-
CellCycle/Hela/index.shtml
5 Raw data from Hess KR, Anderson K, Symmans WF, et al. Pharmacogenomic
predictor of sensitivity to preoperative chemotherapy with paclitaxel and
fluorouracil, doxorubicin, and cyclophosphamide in breast cancer. J Clin Oncol.,
24:4236-4244, 2006
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