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bioTheranostics
 
 

Theros CancerTYPE ID® - Increased Accuracy of Tumor Classification

The Challenges of an Accurate Classification

Often when cancer is identified, the primary origin of the cancer is clear and treatment can begin quickly. However, for some patients, initial diagnostic workup yields an indeterminate result. The diagnostic workup for metastatic patients with uncertain primaries can be cumbersome, lengthy, and costly, averaging nearly $18,000.4 Even after the most thorough clinical workup, accurate identification of the primary cancer site is often not possible.

Theros CancerTYPE ID can assist with differential diagnoses that dramatically alter therapeutic options by identifying the site of origin for cancer. Some common examples include, but are not limited to:

  • Lung (primary) vs. metastatic adenocarcinoma of colon.
  • Mesothelioma vs. lung primary vs. metastatic adenocarcinoma of breast.
  • Hepatocellular or hepatobiliary (primary) vs. metastatic adenocarcinoma of the pancreas.
  • Breast vs. ovarian.
  • Pancreatic vs. other GI.
  • Ovarian vs. colorectal.

Theros CancerTYPE ID Classifies the Following Tumor Types:

Adrenal Meningioma
Brain Mesothelioma
Breast Osteosarcoma
Carcinoid-intestine Ovary-clear
Cervix-adeno Ovary-serous
Cervix-squamous Pancreas
Endometrium Prostate
Gall Bladder Skin-basal-cell
Germ-cell-ovary Skin-melanoma
GIST Skin-squamous
Intestine Soft-tissue-Liposarcoma
Kidney Soft-tissue-MFH
Leiomyosarcoma Soft-tissue-Sarcoma-synovial
Liver Stomach-adeno
Lung-adeno-large-cell Testis-other
Lung-small Testis-Seminoma
Lung-squamous Thyroid-follicular papillary
Lymphoma-B Thyroid-medullary
Lymphoma-Hodgkins Urinary Bladder
Lymphoma-T  

Link to publications

 

References:
1 Ma, et al. Molecular Classification of Human Cancers Using a 92-Gene Real Time Quantitative Polymerase Chain Reaction Assay. Archives of Pathology and Laboratory Medicine, 130: 465-473, 2006.
2 Varadhachary, GR et al. Diagnostic Strategies for Unknown Primary Cancer. Cancer. 100:1776-1785, 2004.
3 Abbruzzese, JL et al. Analysis of a diagnostic strategy for patients with suspected tumors of unknown origin. J Clin Oncol., 13:2094-2103, 1995.
4 Schapira DV, Jarrett AR. The need to consider survival, outcome, and expense when evaluating and treating patients with unknown primary carcinoma. Arch Intern Med.;155:2050-2054, 1995.

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