The Challenges of an Accurate Classification
Often when cancer is identified, the primary origin of the cancer is clear and treatment can begin
quickly. However, for some patients, initial diagnostic workup yields an indeterminate result. The
diagnostic workup for metastatic patients with uncertain primaries can be cumbersome, lengthy,
and costly, averaging nearly $18,000.4 Even after the most thorough clinical workup, accurate
identification of the primary cancer site is often not possible.
Theros CancerTYPE ID can assist with differential
diagnoses that dramatically alter therapeutic options
by identifying the site of origin for cancer. Some
common examples include, but are not limited to:
- Lung (primary) vs. metastatic
adenocarcinoma of colon.
- Mesothelioma vs. lung primary vs.
metastatic adenocarcinoma of breast.
- Hepatocellular or hepatobiliary (primary) vs.
metastatic adenocarcinoma of the pancreas.
- Breast vs. ovarian.
- Pancreatic vs. other GI.
- Ovarian vs. colorectal.
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Theros CancerTYPE ID Classifies the
Following Tumor Types: |
| Adrenal |
Meningioma |
| Brain |
Mesothelioma |
| Breast |
Osteosarcoma |
| Carcinoid-intestine |
Ovary-clear |
| Cervix-adeno |
Ovary-serous |
| Cervix-squamous |
Pancreas |
| Endometrium |
Prostate |
| Gall Bladder |
Skin-basal-cell |
| Germ-cell-ovary |
Skin-melanoma |
| GIST |
Skin-squamous |
| Intestine |
Soft-tissue-Liposarcoma |
| Kidney |
Soft-tissue-MFH |
| Leiomyosarcoma |
Soft-tissue-Sarcoma-synovial |
| Liver |
Stomach-adeno |
| Lung-adeno-large-cell |
Testis-other |
| Lung-small |
Testis-Seminoma |
| Lung-squamous |
Thyroid-follicular papillary |
| Lymphoma-B |
Thyroid-medullary |
| Lymphoma-Hodgkins |
Urinary Bladder |
| Lymphoma-T |
|
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Link to publications
References:
1 Ma, et al. Molecular Classification of Human Cancers Using a 92-Gene
Real Time Quantitative Polymerase Chain Reaction Assay. Archives of
Pathology and Laboratory Medicine, 130: 465-473, 2006.
2 Varadhachary, GR et al. Diagnostic Strategies for Unknown Primary
Cancer. Cancer. 100:1776-1785, 2004.
3 Abbruzzese, JL et al. Analysis of a diagnostic strategy for patients with
suspected tumors of unknown origin. J Clin Oncol., 13:2094-2103, 1995.
4 Schapira DV, Jarrett AR. The need to consider survival, outcome, and
expense when evaluating and treating patients with unknown primary
carcinoma. Arch Intern Med.;155:2050-2054, 1995.
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