Press
Room
Arcturus Bioscience Presents
Results From Two Gene Prognostic Biomarker Studies at 28th
Annual San Antonio Breast Cancer Symposium
Study results validate
prognostic value of proprietary two-gene index
CARLSBAD, Calif., Dec. 6 /PRNewswire/ --
Arcturus Bioscience will present results from two internal
clinical studies validating the company's proprietary two gene
index, HOXB13:IL-17BR (H:I Index), as a potential prognostic
biomarker for the assessment of disease recurrence risk in
breast cancer patients at the 28th Annual San Antonio Breast
Cancer Symposium, taking place December 8-11, 2005.
Arcturus and Massachusetts General Hospital
previously described the discovery of the H:I Index as a predictor
of clinical outcome in breast cancer patients receiving hormonal
therapy. At the Breast Cancer Symposium, Arcturus presents
two independent studies with Mayo Clinic and the Baylor Breast
Cancer Center that confirm this original finding. In the first
study conducted at the Mayo Clinic, the H:I Index is shown
to be significantly associated with outcome in samples from
a prospective randomized trial of 206 breast cancer patients
receiving hormonal therapy. In the second study, with the Baylor
Breast Cancer Center, the H:I Index was analyzed in a retrospective
set of 852 patients. Results from this study further demonstrate
the clinical utility of the H:I Index as a prognostic factor
in breast cancer patients.
Results from both studies will be presented
at the Posters/Discussion Session entitled "Expression Profiles in Prognosis and
Prediction."
Poster Title: A two-gene
expression ratio of HOXB13 and IL-17BR for prediction of
recurrence and survival in women receiving adjuvant tamoxifen.
Presenter: Matthew P. Goetz,
M.D., Breast Clinic, Mayo Clinic,
Rochester, MN
Time: Saturday,
December 10, 5:00 to 7:00 p.m.
in Ballroom A
Poster Title: The
HOXB13:IL17BR Index as a prognostic factor for early breast
cancer.
Presenter: Mark G. Erlander,
Ph.D., Arcturus Bioscience, San Diego,
CA
Time: Saturday, December 10, 5:00
to 7:00 p.m. in Ballroom A
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